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High risk factors for pulmonary fungous infection in intensive care units of neurosurgery

ZHU Wenyu, TAN Liping, CHEN Xiangfeng, HUANG Qiang, LAN Qing

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 299-303 doi: 10.1007/s11684-007-0057-8

Abstract: Conditions such as the severity of primary diseases, long-time coma, long-term use of broad-spectrumantibiotic, abuse of glucocorticoid, the open airway, and some invasive intubations, may be regarded

Keywords： seventeen     incidence     glucocorticoid     broad-spectrum antibiotic     Candidiasis    

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Rapid and long-effective removal of broad-spectrum pollutants from aqueous system by ZVI/oxidants

Sana Ullah, Xuejun Guo, Xiaoyan Luo, Xiangyuan Zhang, Siwen Leng, Na Ma, Palwasha Faiz

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 5, doi: 10.1007/s11783-020-1268-3

Abstract: have been extensively applied to increase the reactivity of the ZVI surface toward the elimination of broad-spectrumSubsequently, the effect of three typical oxidants (H2O2, KMnO4, and NaClO) on broad-spectrum contaminants

Keywords： Zero-Valent Iron (ZVI)     Oxidants     Heavy Metals (HMs)     Metalloids     Nitrate     Phosphate    

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Salmonella-Delivered COBRA-HA1 Antigen Derived from H1N1 Hemagglutinin Sequences Elicits Broad-Spectrum Article

Ram Prasad Aganja, Amal Senevirathne, Chandran Sivasankar, John Hwa Lee

Engineering 2024, Volume 32, Issue 1,   Pages 42-57 doi: 10.1016/j.eng.2023.08.001

Abstract:

A universal vaccine is in high demand to address the uncertainties of antigenic drift and the reduced effectiveness of current influenza vaccines. In this study, a strategy called computationally optimized broadly reactive antigen (COBRA) was used to generate a consensus sequence of the hemagglutinin globular head portion (HA1) of influenza virus samples collected from 1918 to 2021 to trace evolutionary changes and incorporate them into the designed constructs. Constructs carrying different HA1 regions were delivered into eukaryotic cells by Salmonella-mediated bactofection using a Semliki Forest virus RdRp-dependent eukaryotic expression system, pJHL204. Recombinant protein expression was confirmed by Western blot and immunofluorescence assays. Mice immunized with the designed constructs produced a humoral response, with a significant increase in immunoglobulin G (IgG) levels, and a cell-mediated immune response, including a 1.5-fold increase in CD4+ and CD8+ T cells. Specifically, constructs #1 and #5 increased the production of interferon-γ (IFN-γ) producing CD4+ and CD8+ T cells, skewing the response toward the T helper type 1 cell (Th1) pathway. Additionally, interleukin-4 (IL-4)-producing T cells were upregulated 4-fold. Protective efficacy was demonstrated, with up to 4-fold higher production of neutralizing antibodies and a hemagglutination inhibition titer > 40 against the selected viral strains. The designed constructs conferred a broadly protective immune response, resulting in a notable reduction in viral titer and minimal inflammation in the lungs of mice challenged with the influenza A/PR8/34, A/Brisbane/59/2007, A/California/07/2009, KBPV VR-92, and NCCP 43021 strains. This discovery revolutionizes influenza vaccine design and delivery; Salmonella-mediated COBRA-HA1 is a highly effective in vivo antigen presentation strategy. This approach can effectively combat seasonal H1N1 influenza strains and potential pandemic outbreaks.

Keywords： COBRA     Influenza A     Salmonella     Vaccine     Broad spectral protection    

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Presence, dissemination and removal of antibiotic resistant bacteria and antibiotic resistance genes

Qiaowen Tan, Weiying Li, Junpeng Zhang, Wei Zhou, Jiping Chen, Yue Li, Jie Ma

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1120-9

Abstract:

Reviewed the change of ARGs and ARB in full-scale urban drinking water systems.

Conventional processes are more promising than BAC process in ARGs removal.

Mechanisms of ARGs enrichment and spread in BAC filter and DWDSs are discussed.

Raise the need of future research on ARGs and ARB change in building plumbing systems.

Keywords： Antibiotic resistant bacteria     Antibiotic resistance genes     Water source     Drinking water treatment plant    

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Mirror system based therapy for autism spectrum disorders

CHEN Wei, ZHANG Jing, DING Jun

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 344-347 doi: 10.1007/s11684-008-0065-3

Abstract: autisms’ cognitive research and mirror systems and introduces a new hypothesis about the causes of autism spectrum

Keywords： emotional cognition     observation     activation     spectrum     empirical research    

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Distribution of antibiotic resistance genes and their association with bacteria and viruses in decentralized

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 3, doi: 10.1007/s11783-021-1469-4

Abstract:

• Distribution of ARGs in decentralized sewage facilities were investigated.

Keywords： Decentralized sewage treatment facilities     Antibiotic resistance genes     Virus     Metagenomics     Network    

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Environmental Antibiotics and Antibiotic Resistance: From Problems to Solutions

Xin Yu, Virender K. Sharma, Hui Li

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1137-0

Abstract:
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The antibiotic resistome: gene flow in environments, animals and human beings

Yongfei Hu, George F. Gao, Baoli Zhu

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 161-168 doi: 10.1007/s11684-017-0531-x

Abstract:

The antibiotic resistance is natural in bacteria and predates the human use of antibiotics.Numerous antibiotic resistance genes (ARGs) have been discovered to confer resistance to a wide rangeHowever, the antibiotic selection pressure conferred by the use of antibiotics in both human medicineand agriculture practice leads to a significant increase of antibiotic resistance and a steady accumulationemphasis on an ecological point of view, the important research progress regarding the collective ARGs (antibiotic

Keywords： antibiotic resistance     resistome     microbiome     gene flow    

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Solar fuel from photo-thermal catalytic reactions with spectrum-selectivity: a review

Sanli TANG, Jie SUN, Hui HONG, Qibin LIU

Frontiers in Energy 2017, Volume 11, Issue 4,   Pages 437-451 doi: 10.1007/s11708-017-0509-z

Abstract: This paper reviews different approaches for solar fuel production from spectrum-selective photo-thermalThe review begins with the meaning of synergetic effects, and the mechanisms of spectrum-selectivityIn addition, these works are summarized and tabulated based on the operating conditions, spectrum-selectivitydiscussion is finally presented concerning future development of photo-thermal catalytic reactions with spectrum-selectivity

Keywords： photo-thermal catalysis     spectrum-selectivity     solar fuel     full-spectrum    

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Degradation of extracellular genomic, plasmid DNA and specific antibiotic resistance genes by chlorination

Menglu Zhang, Sheng Chen, Xin Yu, Peter Vikesland, Amy Pruden

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1124-5

Abstract:

Extracellular DNA structure damaged by chlorination was characterized.

Integrity of extracellular ARG genetic information after chlorination was determined.

Typical chlorine doses will likely effectively diminish extracellular DNA and ARGs.

Plasmid DNA/ARGs were less readily broken down than genomic DNA.

The Bioanalyzer methodology effectively documented damage incurred to DNA.

Keywords： Antibiotic resistance     Antibiotic resistance genes (ARGs)     Extracellular DNA/ARGs     Chlorination    

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Low-Cost Federated Broad Learning for Privacy-Preserved Knowledge Sharing in the RIS-Aided Internet of

Xiaoming Yuan,Jiahui Chen,Ning Zhang,Qiang Ye,Changle Li,Chunsheng Zhu,Xuemin Sherman Shen,

Engineering doi: 10.1016/j.eng.2023.04.015

Abstract: privacy and improve data learning efficiency in knowledge sharing, we propose an asynchronous federated broadlearning (FBL) framework that integrates broad learning (BL) into federated learning (FL).In FBL, we design a broad fully connected model (BFCM) as a local model for training client data.

Keywords： Knowledge sharing     Internet of Vehicles     Federated learning     Broad learning     Reconfigurable intelligent surfaces    

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Analysis of antibiotic resistance of

Yangyang Yu, Xiaolin Zhu, Guanlan Wu, Chengzhi Wang, Xing Yuan

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1123-6

Abstract:

There was a seasonal difference in antibioticlistitem>

The E. coli in the Yitong River was found to have multiple antibiotic

Keywords： Yitong River     Coliform bacteria     Antibiotic resistance     Escherichia coli    

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Detection of geosmin and 2-methylisoborneol by liquid-liquid extraction-gas chromatograph mass spectrum(LLE-GCMS) and solid phase extraction-gas chromatograph mass spectrum (SPE-GCMS)

MA Xiaoyan, CHEN Beibei, LI Qingsong, ZHANG Qiaoli, GU Guofen

Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 3,   Pages 286-291 doi: 10.1007/s11783-007-0048-7

Abstract: adopted in liquid-liquid extraction (LLE), and the extracts were analyzed by gas chromatograph mass spectrum

Keywords： summer     flocculation     simple     Shanghai     spectrum    

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Antibiotic resistome of : molecular determinants for the emergence of drug resistance

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 693-703 doi: 10.1007/s11684-020-0777-6

Abstract: The widespread clinical and nonclinical uses of antibiotics over the years have combined to select antibiotic-resistantAntibiotic resistome is a dynamic and ever-expanding component in Salmonella.The foundation of resistome in Salmonella is laid long before; therefore, the antibiotic resistometyphi, highlight the seminal work in the resistome of S. typhi and the genes involved in the antibiotic

Keywords： S. typhi     antibiotic resistance     mechanism     resistome     identification methods    

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Influences and mechanisms of nanofullerene on the horizontal transfer of plasmid-encoded antibiotic resistance

Qingkun Ji, Caihong Zhang, Dan Li

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 6, doi: 10.1007/s11783-020-1287-0

Abstract: . • Results provide evidence of nC60 promoting antibiotic resistance dissemination.The spread and development of antibiotic resistance globally have led to severe public health problemsIt has been shown that some non-antibiotic substances can also promote the diffusion and spread of antibiotic

Keywords： Nanofullerene     Sub-minimum inhibitory concentrations     Antibiotic resistance genes     Conjugation     Molecular    

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Title Author Date Type Operation

High risk factors for pulmonary fungous infection in intensive care units of neurosurgery

ZHU Wenyu, TAN Liping, CHEN Xiangfeng, HUANG Qiang, LAN Qing

Journal Article

Rapid and long-effective removal of broad-spectrum pollutants from aqueous system by ZVI/oxidants

Sana Ullah, Xuejun Guo, Xiaoyan Luo, Xiangyuan Zhang, Siwen Leng, Na Ma, Palwasha Faiz

Journal Article

Salmonella-Delivered COBRA-HA1 Antigen Derived from H1N1 Hemagglutinin Sequences Elicits Broad-Spectrum

Ram Prasad Aganja, Amal Senevirathne, Chandran Sivasankar, John Hwa Lee

Journal Article

Presence, dissemination and removal of antibiotic resistant bacteria and antibiotic resistance genes

Qiaowen Tan, Weiying Li, Junpeng Zhang, Wei Zhou, Jiping Chen, Yue Li, Jie Ma

Journal Article

Mirror system based therapy for autism spectrum disorders

CHEN Wei, ZHANG Jing, DING Jun

Journal Article

Distribution of antibiotic resistance genes and their association with bacteria and viruses in decentralized

Journal Article

Environmental Antibiotics and Antibiotic Resistance: From Problems to Solutions

Xin Yu, Virender K. Sharma, Hui Li

Journal Article

The antibiotic resistome: gene flow in environments, animals and human beings

Yongfei Hu, George F. Gao, Baoli Zhu

Journal Article

Solar fuel from photo-thermal catalytic reactions with spectrum-selectivity: a review

Sanli TANG, Jie SUN, Hui HONG, Qibin LIU

Journal Article

Degradation of extracellular genomic, plasmid DNA and specific antibiotic resistance genes by chlorination

Menglu Zhang, Sheng Chen, Xin Yu, Peter Vikesland, Amy Pruden

Journal Article

Low-Cost Federated Broad Learning for Privacy-Preserved Knowledge Sharing in the RIS-Aided Internet of

Xiaoming Yuan,Jiahui Chen,Ning Zhang,Qiang Ye,Changle Li,Chunsheng Zhu,Xuemin Sherman Shen,

Journal Article

Analysis of antibiotic resistance of

Yangyang Yu, Xiaolin Zhu, Guanlan Wu, Chengzhi Wang, Xing Yuan

Journal Article

Detection of geosmin and 2-methylisoborneol by liquid-liquid extraction-gas chromatograph mass spectrum(LLE-GCMS) and solid phase extraction-gas chromatograph mass spectrum (SPE-GCMS)

MA Xiaoyan, CHEN Beibei, LI Qingsong, ZHANG Qiaoli, GU Guofen

Journal Article

Antibiotic resistome of : molecular determinants for the emergence of drug resistance

Journal Article

Influences and mechanisms of nanofullerene on the horizontal transfer of plasmid-encoded antibiotic resistance

Qingkun Ji, Caihong Zhang, Dan Li

Journal Article